"Acute Leukemia: The Scientists Perspective and Challenge" ed. by Mariastefania Antica
ITAe | 2011 | ISBN: 9789533075532 | 438 pages | PDF | 10 MB
This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease.
The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory.
The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies.
The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients.
Part 1 Introduction
1 Classification of Acute Leukemia
2 Diagnosis of Acute Leukemia in Under-Resourced Laboratories
Part 2 Molecular Mechanisms and Markers
3 The PI3K/PKB Signaling Module in Normal and Malignant Hematopoiesis
4 Lymphocyte Commitment and Ikaros Transcription Factors
5 Epigenetics and Targeted Therapy in Acute Leukemia
6 Molecular Markers for Risk Stratification in Adult Acute Myeloid Leukemia with Normal Cytogenetics
7 Trafficking of Acute Leukemia Cells - Chemokine Receptor Pathways that Modulate Leukemia Cell Dissemination
8 Biochemistry of the Mixed Lineage Leukemia 1 (MLL1) Protein and Targeted Therapies for Associated Leukemia
Part 3 Pediatric Acute Leukemia
9 Diagnostics of Molecular Markers in Childhood Acute Leukaemia Using Biochips
10 Pediatric Acute Myeloid Leukemia
11 Pediatric Natural Killer Cell Malignancy
12 Leukemogenesis in Down Syndrome
Part 4 Treatment and Future Prospects
13 Cord Blood Transplantation in Adults with Acute Leukemia
14 Acute Lymphoblastic Leukemia in Adolescents and Young Adults
15 Evidence-Based Guided Interventions in Acute Leukemia
16 Hematologic Malignancies in Pregnancy
17 Chemotherapy Toxicity in Patients with Acute Leukemia
18 Vitamin D and Acute Myeloid Leukemia
with TOC BookMarkLinks
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